KREATiS
Kreatis replacing experimentation for reach - REACH alternative laboratory testing
Kreatis - an alternative to experimentation for REACH - REACH alternative experimentation

Available models for organic compounds

The main objectives of the KREATiS iSafeRat® platform are to provide the highest accuracy predictions at a fraction of price and cost compared to laboratory studies. These models are supported by the appropriate documents for regulatory compliance.

Models: endocrine disruption screening

Aim: to predict “no direct Endocrine Disruptor potential” with high confidence
Method proposing 3 screening steps:

Use of traditional MechoA scheme but updated with specific rules to specifically map EDCs
3D Molecular Modelling of the substance structure to check if the molecule docks with an endocrine receptor
Use of off-the-shelf tools (structural alerts e.g. for steroid binding) to strengthen our prediction using a consensus approach

Get ready to work with iSafeRat® when and where you want

iSafeRat Desktop is coming soon!

No internet connection required
Instant prediction reports
Batch mode support for multiple substances
A dedicated module for mixture toxicity
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KREATiS, Knowledge & research in environment and toxicology in silico

Knowledge & research in environment and toxicology in silico