Specialty : Toxicology
The project will be based on one of these three options to be decided by CEHTRA/KREATiS on the basis of internal prioritization and appropriate candidate eligibility:
1. Research & Development of alternative to oral toxicity and reprotoxicity
For practical reasons, the project will focus on esters and above mentioned endpoints. However, it could be easily extended to include the acute oral toxicity endpoint and to other chemical classes, especially those where toxicity is not expected to be significant such as many narcotics.
The tool or model to be developed must be statistically validated and scientifically robust, i.e. satisfying the criteria mentioned in REACH Annex XI and ECHA guidance R-6.
The purpose of this Research & Development project is to develop a method, either an approach, a tool or a model, to predict the absence of repeated dose oral toxicity and reprotoxicity of esters. These endpoints are required in Annex VIII of REACH. Weight of evidence (WoE) approach or read-across principles will be applied using an adequate and reliable documentation leading to a method which will be relevant to a whole chemical class such as esters.
The major goal behind considering this endpoint is to understand the common trends between the results derived from different Guinea Pig and Human sensitisation tests. This exercise will then enable us to identify the appropriate test protocols for each chemical class and to evaluate which protocol is most likely to provide false positives. Based on the derived results, the shortcomings of existing sensitisation tests will then be evaluated.
The reliable test results collected during this exercise will be used to develop a high quality in-silico model to predict the sensitisation potential of new chemicals.
3. High Accuracy QSAR development for acute inhalation toxicity
The purpose is to develop a High-Accuracy Quantitative Structure-Activity Relationship (HA-QSAR) for acute inhalation toxicity on mammals.
This Research & Development project will be an opportunity to develop a reliable toxicological QSAR based on thermodynamic principles (Mackay et al., 2009) to determine with high accuracy and reliability, the value of acute toxicity by inhalation for gases and highly volatile substances, as required in Annex VIII of REACH if the route of exposure by inhalation is the most relevant in humans. This model will have to be statistically validated and will satisfy the five OECD principles for model validation before it is released into the public domain (OECD (2004) Principles for the validation, for regulatory purposes, of (Quantitative) Structure Activity-Relationship Models).
French Master 1 or 2 (or equivalent) in toxicology.
If you are interested by this job offer, please send your resume and cover letter to email@example.com
Please mention the following reference: KRE/TOX/STA/Jun2014.