IN SILICO TOXICOLOGY


AN INTRODUCTION TO TOXICOLOGICAL PRINCIPLES AND METHODS FOR PREDICTING HUMAN HEALTH EFFECTS WITHOUT RESORTING TO EXPERIMENTAL STUDIES


Trainer
Carole CHARMEAU


Carole CHARMEAU, PhD

Managing Director and Expert Toxicologist

Email: carole.charmeau@kreatis.eu

Trainer
Mélanie DELANNOY


Mélanie DELANNOY, PhD

QSAR Model Developer and Chemist

Email: melanie.delannoy@kreatis.eu


Toxicologists, Regulatory affairs specialists,
risk assessors, Product stewards,
REACH consultants


Courses held at KREATiS offices,
by video-conference (e.g. Microsoft Teams or Zoom)
or at any location of your choice*



1 day



1,100 € excl. VAT per participant and per day

*for locations chosen by the client, travel costs must be included in the total price

OBJECTIVES

► Grasp the principles of toxicology which can be predicted by in silico tools
► Discover QSAR predictions and other in silico methods for obtaining critical physicochemical and toxicological endpoints
► Learn to assess the reliability of predictions derived using the in silico methods covered
► Learn to generate regulatory formats for prediction reports for regulatory submission of the read-across and QSAR results

PROGRAMME
Part 1

A background understanding to toxicological human health effects and related physico-chemical properties

Part 2

► Introduction to QSARs and other alternative in silico methods in toxicology
► Overview of in silico tools (QSAR toolbox, iSafeRat, VEGA, OPERA, TEST, Danish QSAR Database…) and functionalities

Part 3

in silico profiling for Toxicological endpoints: Skin Sensitization and Genotoxicity
► Understanding in silico predictions (alert interpretation)
► Where to find information to be able to asses prediction reliability
► Training participants can choose the endpoints and the chemical structures to be used for specific case studies if provided in advance (be-spoke training).

Part 4

Understanding in silico prediction report formats and their validation (QPRF and QMRF)

French version available : here