Your in silico expert, offering you our services to screen the hazard of your substance, complete your regulatory dossier, boost your R&D and reduce tests on animals in the most time and cost efficient way possible.
We exist to understand the mechanistic interactions between chemical and biological matrices and quantify the impact on human health and the environment.
4 pillars of our activity
The combination of our unique tools will help you to fill your datagaps with the best in silico study predictions available, meeting the 5 OECD principles for the validation of QSARs and regulatory format requirements for a host of dossier submissions and updates notably for REACH and CPSR, ICH M7, Medical devices, but increasingly for aspects of Plant Protection Products, Biocides and Pharmaceuticals.
In silico consulting
Support with Regulatory documents iSafeRat® & for third-party tools for endpoints requiered in dossier submissions.
The power of KREATiS in silico predictions
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Vertebrate animals saved by the work of KREATiS using in silico methods instead of animal experimentation.
Estimation based uniquely on the number of acute and chronic fish toxicity studies realized by KREATiS from 01/2014 replacing 42 fish in acute OECD 203 and 80 fish eggs in chronic OCDE 210 in vivo studies.
The expertise of model developers
Simply obtaining a prediction is the easy part but having confidence in the reliability of the result requires experience in modelling using multidisciplinary approaches, in silico good practice and unbiased scientific and mechanistic interpretation. We take pride in sharing our knowledge with you to help you obtain information for your regulatory needs, thanks to our homegrown tools.
iSafeRat® toolbox
iSafeRat® (in silico Algorithms For Environmental Risk And Toxicity) is the KREATiS-made toolbox of High Accuracy QSAR (HA-QSAR) modules produced by KREATiS.
Our mission is to make iSafeRat® the most reliable and accurate in silico tool available to replace all kinds of experimental studies related to human health and the environment and notably offers chronic study predictions for ecotoxicity.
MechoA
MechoA (Mechanisms of Action) MechoA is a structural alerts-based decision tree to predict the mechanisms of toxic action of a large range of chemical structures in different biological species.
It has been developed in collaboration with Unilever and Liverpool John Moores University, becoming MechoA+, which is made freely available in the OECD QSAR Toolbox. Internal research at KREATiS further improves the model regularly in the form of MechoA Premium, which is available only in iSafeRat® Desktop.
MechoApedia
Open the door to a clear scientific explanation and better understanding of the mechanisms of toxicity action.
To help the public learn more about the various mechanisms of toxic action that exist and the typical associated chemical structures, KREATiS has designed this interactive pedagogic free tool presenting the different MechoA classes.
La French Touch by KREATiS
We are proud to be one of the first French company to work for the 3Rs, with members from different companies who fight to re-think experimentation.
Become a computational specialist
With KREATiS intensive and hands-on training, master your skills and learn how to use software dedicated to predictions to grow your own expertise. The quality of our training is certified each year by the French Certification Qaliopy.
OECD QSAR Toolbox
An introduction to replacing experimentation including hands on experience using the OECD toolbox for read-across and QSAR modelling.
Read moreIn silico ecotoxicology
An introduction to regulatory and in silico ecotoxicological principles and methods for predicting hazard and fate without resorting to experimental studies.
Read moreIn silico toxicology
An introduction to regulatory and in silico toxicological principles and methods for predicting human health effects without resorting to experimental studies.
Read more
What they say about us
The following entities have honoured us by allowing us to quote them on our website.
No quote has been included without the express permission of the person cited and their legal entity.
“The QSAR estimate for water solubility as well as an estimate for the chronic Daphnia toxicity for a difficult to test substance was our first collaboration with KREATIS. I appreciated the scientifically well-founded communication, always in a timely manner. All documents were carefully prepared and timelines fully met. It was a very good start and I’m looking forward to any further collaboration with KREATIS.”
Dr. Markus Schwarz
Biologist, Chemist, Certified Ecotoxicologist (GDCh/SETAC GLB)
Forschungs- und Beratungsinstitut Gefahrstoffe GmbH (FoBiG), Freiburg, Germany
“I have to say you did a good job with the interface and the report functionality of iSafeRat® Desktop v1.0. Very clear and intuitive, which made it easy to reproduce the results and document it.”
Doris Hirmann,
ECHA Computational Unit
“We work regularly with KREATiS to further the science in R&D projects and as a complement to our empirical ecotoxicity studies especially for mixtures. We believe that the combined approach of using laboratory and in silico approaches in aquatic toxicity studies on mixtures (known as WAF tests) is the best way to scientifically justify the WAF method in regulatory use: The empirical laboratory result validates the in silico prediction; the thermodynamically determined in silico prediction mechanistically explains the laboratory result.”
Nicolas Delpit, Study Director Ecotoxicology;
Sylvie Betat Head of Unit
“In recent years Environment and Climate Change Canada (ECCC) has been profiling new and existing substances for mechanisms and modes of action both for substance prioritization and risk assessment.
Similar concepts found in the MechOA module in iSafeRat were also developed for version 2.0 of ECCC’s Ecological Risk Classification (ERC) system for prioritizing organic substances for further evaluation in Canada. ECCC therefore has a good understanding of the approaches used in iSafeRat for MechoA determination.
We have found that iSafeRat offers one of the few up to date software packages that can link MechoA profiling to high quality QSAR predictions. The detailed information provided in model output with respect to domain of applicability and prediction confidence provides transparency and improves regulatory acceptance and application of results.
The continued effort by the model developers to expand and improve the MechoA and QSAR aspects of iSafeRat is also a key aspect of ECCC’s support for the software.”
Mark Bonnell, Senior Scientific Advisor, Science and Risk Assessment Directorate,
Environment and Climate Change Canada
“The iSafeRat® toolbox offers both ease of use and high accuracy results.
We rely on the tool extensively for multiple applications within Mane:
- First, to produce study predictions as stand-alone values for submission of regulatory dossiers at home and abroad but also to define testing strategies;
- Second, to define strategy for new substances
- And third, to hunt out lower quality laboratory studies in our database so we can repeat them, if necessary ensure that only the very best data are available for Mane’s products.”
Jocelyne Kurtz, Head of Global Registration, Global Regulatory Affairs and Product Safety at Mane
