IN SILICO ECOTOXICOLOGY


AN INTRODUCTION TO ECOTOXICOLOGICAL PRINCIPLES AND METHODS FOR PREDICTING HAZARD AND FATE WITHOUT RESORTING TO EXPERIMENTAL STUDIES

Trainer
Paul THOMAS


Paul THOMAS, PhD, ERT

President, Model Developer and Expert Ecotoxicologist

Email: paul.thomas@kreatis.eu

Trainer
Franklin BAUER


Franklin BAUER, PhD

QSAR Model Developer and Chemist

Email: franklin.bauer@kreatis.eu

Trainer
Pascal BICHEREL


Pascal BICHEREL, MSc

QSAR Model Developer and Ecotoxicologist

Email: pascal.bicherel@kreatis.eu

Pré-requis

Ecotoxicologists, Regulatory Affairs Specialists, Environmental Risk Assessors, Product Stewards, REACH Consultants

Courses held at the KREATiS offices, by videoconference or at your premises*.

*Travel expenses to be paid by the client.

1 day - Duration adapted to the profile and skill level of the client and the objectives to be achieved.


1100€ net per participant and per day of training

OBJECTIVES

► Mastering the principles of ecotoxicology which can be predicted by AI tools.
► Discover QSAR predictions and other in silico methods for obtaining critical physicochemical and ecotoxicological endpoints.
► Learn to assess the reliability of predictions derived using the in silico methods covered.
► Learn to generate regulatory formats for prediction reports for regulatory submission of the Read-Across and QSAR results.

PROGRAMME
Part 1

A background understanding to ecotoxicological hazard assessment and related physico-chemical properties

Part 2

► Introduction to QSARs and alternative (in silico) methods in ecotoxicology.
► Overview of in silico tools (EPIWIN/ECOSAR; iSafeRat, VEGA, OPERA, TEST…) and functionalities.

Part 3

Read-Across and QSAR predictions for:
► Critical physico-chemical endpoints
► Ecotoxicological and environmental endpoints
► Ecotoxicological and environmental endpoints
► Training participants can choose the endpoints and the chemical structures to be used for specific case studies if provided in advance.

Part 4

Understanding Read-Across/QSAR prediction report formats and their validation :
► Generation of prediction reports which could be used for regulatory purposes.

Access time: 3 months
Teaching aids

- Digital and paper presentation material
- Free software to download and associated case studies

Evaluation methods

- Initial knowledge assessment grid
- Pre- and post-training assessment quizzes

The content of the training and the teaching methods are adapted to the profile and needs of the client.