OECD QSAR TOOLBOX


AN INTRODUCTION TO REPLACING EXPERIMENTATION USING READ-ACROSS AND QSAR MODELLING


Trainer
Pascal BICHEREL


Pascal BICHEREL, MSc

QSAR Model Developer and Ecotoxicologist

Email: pascal.bicherel@kreatis.eu

Trainer
Carole CHARMEAU


Carole CHARMEAU, PhD, ERT

Managing Director and Expert Toxicologist

Email: carole.charmeau@kreatis.eu

Trainer
Paul THOMAS


Paul THOMAS, PhD, ERT

President, Model Developer and Expert Ecotoxicologist

Email: paul.thomas@kreatis.eu

Prerequisites

- Have a degree in toxicology and/or chemistry
- Be in charge of risk assessment and/or regulatory affairs

Courses held at the KREATiS offices, by videoconference or at your premises*.

*Travel expenses to be paid by the client.

1 to 2 days - Duration adapted to the profile and skill level of the client and the objectives to be achieved.


1100€ net per participant and per day of training

OBJECTIVES

► Understanding the OECD QSAR Toolbox interface and functionalities.
► Be able to use the tool to obtain profiling and Read-Across/QSAR predictions for various physicochemical, ecotoxicological and human health endpoints.
► To assess the reliability in predictions derived using the OECD QSAR Toolbox.
► To generate prediction reports for the read-across and QSAR results.

PROGRAMME
Part 1

Basics :
► Introduction to OECD QSAR Toolbox
► Overview of all the tool functionalities

Part 2

Profiling and category formation :
► Introduction to profiling and category formation approaches in the tool

Part 3

Read-Across and QSAR predictions :
► Physicochemical endpoints
► Ecotoxicological and environmental endpoints
► Human health endpoints
► Training participants can choose the endpoints and the chemical structures to be used as case studies

Part 4

Read-Across/QSAR prediction reports :
► Generation of prediction reports which could be used for regulatory purposes

Access time: 3 months
Teaching aids

- Digital and paper presentation material
- Free software to download and associated case studies

Evaluation methods

- Initial knowledge assessment grid
- Pre- and post-training assessment quizzes

The content of the training and the teaching methods are adapted to the profile and needs of the client.