Paul THOMAS has a PhD in aquatic ecotoxicology and more than 20 years' experience with industrial chemicals, agrochemicals and biocides gained initially at CIT (now Charles River) where he set up the ecotoxicology service and was study director for 4 years, ATOFINA (now ARKEMA) where he practiced ecotoxicology and Risk Assessment for existing substances and then AkzoNobel (now Nouryon) where he was head of department, head of the ecotoxicology GLP and research laboratories and organiser of REACH services for the company for over 6 years. He joined CEHTRA in 2008 as director of CEHTRA Lyon specialising in REACH-related services and is manager of the CEHTRA ecotoxicology team and contributed strongly to numerous successful registrations out of the >600 substances that CEHTRA registered since 2010 and has been working in the area of predictive ecotoxicology since this time. In 2014, while retaining all his roles in CEHTRA, Paul founded KREATiS and was nominated CEO KREATiS is a start-up company specialising in the creation of high accuracy QSARs to replace experimentation for REACH and other regulations. In 2020 he bought the company together with a human health expert, Dr Carole Charmeau, and they have worked hard with the KREATiS team to bring the company to new heights, adding multiple models to their iSafeRat® model suite, and embracing new technologies such as 3D docking models for studying protein-ligand interactions.
Carole CHARMEAU holds a PhD in Toxicology and is qualified as a European Registered Toxicologist (ERT). She has 20 years of experience with industrial chemicals and agrochemicals gained at IARC and then in industry and consulting. She joined CEHTRA in 2008 as a senior toxicologist to strengthen the REACH team at Lyon, providing strategy to assess the hazard of chemicals for human health using alternative methods such as read-across and weight of evidence approach. Carole is also specialised in the derivation of Derived No Effect Levels (DNEL) for the human. She developped the IFRA consumer exposure scenarios guidance (2011) and was involved in ECHA’s project for the consumer risk assessment developing scenarios in ConsExpo to be imported in CHESAR. Since 2016, Carole has participated in human health R&D projects at KREATiS, a daughter company of CEHTRA created in 2014 and specialised in the development of High Accuracy In-Silico models to predict regulatory experimental endpoints such as skin/eye irritation potential or skin sensitisation potential of chemicals. In January 2018, Carole joined KREATiS as Managing Director of the company and in 2020 she became company owner together with an ecotoxicology expert, Dr Paul Thomas, and together with the KREATiS team they have worked hard with to bring the company to new heights in a quest to create and offer the most accurate state-of-the-science models possible.
Pascal BICHEREL has obtained his Master’s degree in environmental sciences from Graduate School of Life Sciences of Toulouse in 2013. During his academic studies he gained skills in molecular and cell biology and organic chemistry. As a part of his first internship at INRA (National Institute of Agronomic Research) in Versailles-Grignon, he studied the impact of a pesticide exposure on earthworms. During the second year of his Master’s degree, he carried out his internship at CEHTRA to develop predictive models for the acute aquatic toxicity of mixtures. In October 2013, he joined CEHTRA, then its subsidiary, KREATiS as its first employee. Currently, he is using his expertise in designing new in silico models of High Accuracy-QSAR (HA-QSARs) at KREATiS in order to replace experimentation for REACH.
Franklin BAUER obtained his Master’s and Engineer’s degree in organic, bioorganic and therapeutic chemistry from National Graduate School of Chemistry of Mulhouse (ENSCMu) in 2014. During his studies, he gained a strong knowledge of organic chemistry and also learned molecular modelling, software programming and chemical analysis methods. Between december 2014 and december 2017, he did a PhD fellowship in collaboration with KREATiS and University of Haute-Alsace, thanks to a "CIFRE", a funding from French government. This PhD focussed on a better characerisation of mecanisms of toxic action based on the molecular structure. Since then, Franklin is working at KREATiS on QSAR models and software development.
Zlatomir has an interdisciplinary training in biology and informatics starting with a diploma in life science from the University of Lyon in 2011 followed by a Bachelor’s degree at the University of Perpignan and a Master’s degree at the University of Montpellier in 2014 specializing in bioinformatics. He obtained a PhD in Structural biology and Nanobiology in 2019 from the University of Grenoble on an ambitious molecular modeling project. During this period, he studied the molecular function of mammalian Kir3 channels using high-throughput molecular dynamics simulations, related computational techniques and wet-lab experiments.
Zlatomir joined the KREATiS team in mid-2019 to manage the in-situ 3D molecular modeling capabilities of the company especially in its Endocrine Disruption project. The department aims at providing our clients with prediction services for quantified characterization of the interactions between small molecules and selected biological targets. Currently available or in the pipeline: de-novo and homology modeling, molecular docking, molecular dynamics simulations and computation of the free energies of interaction in molecular complexes.
Antoine is a student in his 4th year in UTBM (Université de Technologie Belfort-Montbéliard) informatics engineer school, specialising in software development. He's been working with KREATiS since mid-2017. He is one of the main contributors behind the development of KREATiS' tools iSafeRat® Online and iSafeRat® Desktop.
Ludovic FARAVEL received his Master degree in Environment Management in University of Lorraine (UL) in Metz in 2020. During his studies, he developed skills in ecotoxicology and in ecosystems analysis. During his Master's degree, he implemented normalised ecotoxicity assays in order to determine toxicity of contaminated soils due to rare-earth metals. In 2021, he started a CIFRE thesis at KREATiS in collaboration with the Laboratoire Interdisciplinaire des Environnement Continentaux (LIEC) from UL. This thesis project aims to further investigate the ecotoxicity of cosmetic products to various aquatic organisms. Finally the findings of these assays will be use to adapt and develop an in silico tool to predict complex mixtures of chemicals.