News collaboration Unilever


KREATiS has signed an agreement to collaborate with Unilever, joining an on-going project involving Liverpool John Moores University (LJMU), to update the scheme on Mechanisms of toxic Action (MechoA).

The first MechoA scheme was published by KREATiS in 20181 and classified molecular initiating events (MIE) between organic chemical substances and biological matrices leading to structural alerts for human health and the environment. Since then, the scheme has gone through several iterations and is now in the final phase of acceptance as a profiler in a future update to the OECD QSAR Toolbox. Similar thinking to that of KREATiS was shared by Unilever and Prof. Mark Cronin of LJMU who, in collaboration with Environment and Climate Change Canada, have recently published2 a MIE based strategy following along the same lines and adding cross-species susceptibility to several MIEs for multiple aquatic species.

The aim of this collaborative research is to align and combine the Unilever/LJMU findings with those of KREATiS in order to update the MechoA scheme and ultimately make a new enhanced version available in the OECD Toolbox and other platforms.

1Franklin Bauer, Paul Thomas, Samuel Fouchard, Neunlist Serge (2018) High-accuracy prediction of Mechanisms of Action using structural alerts. Computational Toxicology, Volume 7, Pages 36-45

2Maria Sapounidou, David J. Ebbrell, Mark A. Bonnell, Bruno Campos, James W. Firman, Steve Gutsell, Geoff Hodges, Jayne Roberts, and Mark T. D. Cronin Development of an Enhanced Mechanistically Driven Mode of Action Classification Scheme for Adverse Effects on Environmental Spec Environ. Sci. Technol. 2021, 55, 3, 1897–1907

Newsletter November 2020

Dear friends and collaborators,

This special edition of our newsletter will summarise recent events and achievements involving KREATiS over the last year. The year 2020, despite the unfortunate turn of events experienced across the world, has clearly not diminished the desire of companies, regulators and academics alike to advance our understanding of intrinsic properties of the molecules we produce and use on a daily basis. Quite the opposite, it has perhaps highlighted the fragility of our globe and pushed us to take more care in the way we assess cost and benefits to human health and environmental.

In brief, the last 12 months have been remarkable for KREATiS. During this time (and most recently) we have become a truly independent, privately owned, R&D organisation, perhaps the only one of its kind on the planet; we have received OECD recognition of the MechoA profiler which is currently being included in the OECD Toolbox; we have recruited a 3D modeller and invested in super-computer hardware to boost our digital revolution technology; we have worked on a battery of tests to provide strong evidence of the potential for endocrine disruption (or indeed, the lack of it!) in a diverse range of organic molecules; and won an exciting challenge open to start-ups across the globe. Last year we rolled-out and have tirelessly continued to work on our new desktop version of iSafeRat®, which has now become the mainstay of our High Accuracy QSAR modelling suite; and still on the desktop version, we have just released the biggest update ever on the iSafeRat® software. For the rapidly increasing number of you who have become iSafeRat® Desktop users, you will have automatically received the new downloadable version 2.0.10. Finally, we have continued to collaborate in research projects and diverse publications in both environment and human health. 

Discover more details in the PDF below!


Press release

KREATiS Management buyout

L’Isle d’Abeau (38), France:

On 7 August, 2020, KREATiS SAS, a subsidiary of the CEHTRA group, underwent a management buyout. The spin-off by CEHTRA represents a strategic decision to:

- Empower KREATiS with total autonomy, including expanding its partnerships and accessing new sources of funding for its ambitious research program.
- Leverage CEHTRA’s consultancy expertise on behalf of its clients and continue to deliver industry leading solutions.

Xavier Dennery, President of CEHTRA said: "CEHTRA is proud of the progress made by its subsidiary KREATiS, which has now become a major player, and to which CEHTRA wishes all possible success. We are confident in the talent of the KREATiS team to enable it to carry out its many ambitious projects.”

Paul Thomas, president and founder of KREATiS who, returning to his passion for the science of in silico modelling in the service of human health and the environment, highlighted “the great adventure shared with CEHTRA for 12 years, which now continues in different directions. We are looking forward to putting all our energy into new and exciting projects in the area of alternative testing methods.”