The following entities have honoured us by allowing us to quote them on our website. No quote has been included without the express permission of the person cited and their legal entity:

ECHA: Doris Hirmann, ECHA Computational Unit (March 2020)

“I have to say you did a good job with the interface and the report functionality of iSafeRat® Desktop v1.0. Very clear and intuitive, which made it easy to reproduce the results and document it.”

Environment Canada: Mark Bonnell, Senior Scientific Advisor, Science and Risk Assessment Directorate, Environment and Climate Change Canada

“In recent years Environment and Climate Change Canada (ECCC) has been profiling new and existing substances for mechanisms and modes of action both for substance prioritization and risk assessment. Similar concepts found in the MechOA module in iSafeRat were also developed for version 2.0 of ECCC’s Ecological Risk Classification (ERC) system for prioritizing organic substances for further evaluation in Canada. ECCC therefore has a good understanding of the approaches used in iSafeRat for MechoA determination. We have found that iSafeRat offers one of the few up to date software packages that can link MechoA profiling to high quality QSAR predictions. The detailed information provided in model output with respect to domain of applicability and prediction confidence provides transparency and improves regulatory acceptance and application of results. The continued effort by the model developers to expand and improve the MechoA and QSAR aspects of iSafeRat is also a key aspect of ECCC’s support for the software.”

LPL: Nicolas Delpit Study Director Ecotoxicology; Sylvie Betat Head of Unit

“We work regularly with KREATiS to further the science in R&D projects and as a complement to our empirical ecotoxicity studies especially for mixtures. We believe that the combined approach of using laboratory and in silico approaches in aquatic toxicity studies on mixtures (known as WAF tests) is the best way to scientifically justify the WAF method in regulatory use: The empirical laboratory result validates the in silico prediction; the thermodynamically determined in silico prediction mechanistically explains the laboratory result”

Mane : Jocelyne Kurtz, Head of Global Registration, Global Regulatory Affairs and Product Safety at Mane

“The iSafeRat® toolbox offers both ease of use and high accuracy results. We rely on the tool extensively for multiple applications within Mane:

First, to produce study predictions as stand-alone values for submission of regulatory dossiers at home and abroad but also to define testing strategies;

Second, to define strategy for new substances

And third, to hunt out lower quality laboratory studies in our database so we can repeat them, if necessary ensure that only the very best data are available for Mane’s products”