IN SILICO TOXICOLOGY
AN INTRODUCTION TO TOXICOLOGICAL PRINCIPLES AND METHODS FOR PREDICTING HUMAN HEALTH EFFECTS WITHOUT RESORTING TO EXPERIMENTAL STUDIES
Trainer
Carole CHARMEAU
Carole CHARMEAU, PhD, ERT
Managing Director and Expert Toxicologist
Email: carole.charmeau@kreatis.eu
Trainer
Etienne BOURGART
Pré-requis
Toxicologists, Regulatory Affairs Specialists, Risk Assessors, Product Stewards, REACH Consultants
Courses held at the KREATiS offices, by videoconference or at your premises*.
*Travel expenses to be paid by the client.
1 day - Duration adapted to the profile and skill level of the client and the objectives to be achieved.
1100€ net per participant and per day of training
OBJECTIVES
► Mastering the principles of toxicology which can be predicted by in silico tools
► Discover QSAR predictions and other in silico methods for obtaining critical physicochemical and toxicological endpoints
► Learn to assess the reliability of predictions derived using the in silico methods covered
► Learn to generate regulatory formats for prediction reports for regulatory submission of the read-across and QSAR results
PROGRAMME
Part 1
A background understanding to toxicological human health effects and related physico-chemical properties
Part 2
► Introduction to QSARs and other alternative in silico methods in toxicology
► Overview of in silico tools (QSAR toolbox, iSafeRat, VEGA, OPERA, TEST, Danish QSAR Database…) and functionalities
Part 3
in silico profiling for Toxicological endpoints: Skin Sensitization and Genotoxicity
► Understanding in silico predictions (alert interpretation)
► Where to find information to be able to asses prediction reliability
► Training participants can choose the endpoints and the chemical structures to be used for specific case studies if provided in advance (be-spoke training).
Part 4
Understanding in silico prediction report formats and their validation (QPRF and QMRF)
- Digital and paper presentation material
- Free software to download and associated case studies
- Initial knowledge assessment grid
- Pre- and post-training assessment quizzes