IN SILICO TOXICOLOGY


AN INTRODUCTION TO TOXICOLOGICAL PRINCIPLES AND METHODS FOR PREDICTING HUMAN HEALTH EFFECTS WITHOUT RESORTING TO EXPERIMENTAL STUDIES


Trainer
Carole CHARMEAU


Carole CHARMEAU, PhD

Managing Director and Expert Toxicologist

Email: carole.charmeau@kreatis.eu

Pré-requis

Toxicologists, Regulatory Affairs Specialists, Risk Assessors, Product Stewards, REACH Consultants

Courses held at the KREATiS offices, by videoconference or at your premises*.

*Travel expenses to be paid by the client.

1 day - Duration adapted to the profile and skill level of the client and the objectives to be achieved.


1100€ net per participant and per day of training

OBJECTIVES

► Mastering the principles of toxicology which can be predicted by in silico tools
► Discover QSAR predictions and other in silico methods for obtaining critical physicochemical and toxicological endpoints
► Learn to assess the reliability of predictions derived using the in silico methods covered
► Learn to generate regulatory formats for prediction reports for regulatory submission of the read-across and QSAR results

PROGRAMME
Part 1

A background understanding to toxicological human health effects and related physico-chemical properties

Part 2

► Introduction to QSARs and other alternative in silico methods in toxicology
► Overview of in silico tools (QSAR toolbox, iSafeRat, VEGA, OPERA, TEST, Danish QSAR Database…) and functionalities

Part 3

in silico profiling for Toxicological endpoints: Skin Sensitization and Genotoxicity
► Understanding in silico predictions (alert interpretation)
► Where to find information to be able to asses prediction reliability
► Training participants can choose the endpoints and the chemical structures to be used for specific case studies if provided in advance (be-spoke training).

Part 4

Understanding in silico prediction report formats and their validation (QPRF and QMRF)

Access time: 3 months
Teaching aids

- Digital and paper presentation material
- Free software to download and associated case studies

Evaluation methods

- Initial knowledge assessment grid
- Pre- and post-training assessment quizzes

The content of the training and the teaching methods are adapted to the profile and needs of the client.