IN SILICO TOXICOLOGY
AN INTRODUCTION TO TOXICOLOGICAL PRINCIPLES AND METHODS FOR PREDICTING HUMAN HEALTH EFFECTS WITHOUT RESORTING TO EXPERIMENTAL STUDIES
Trainer
Carole CHARMEAU
Pré-requis
Toxicologists, Regulatory Affairs Specialists, Risk Assessors, Product Stewards, REACH Consultants
Courses held at the KREATiS offices, by videoconference or at your premises*.
*Travel expenses to be paid by the client.
1 day - Duration adapted to the profile and skill level of the client and the objectives to be achieved.
1100€ net per participant and per day of training
OBJECTIVES
► Grasp the principles of toxicology which can be predicted by in silico tools
► Discover QSAR predictions and other in silico methods for obtaining critical physicochemical and toxicological endpoints
► Learn to assess the reliability of predictions derived using the in silico methods covered
► Learn to generate regulatory formats for prediction reports for regulatory submission of the read-across and QSAR results
PROGRAMME
Part 1
A background understanding to toxicological human health effects and related physico-chemical properties
Part 2
► Introduction to QSARs and other alternative in silico methods in toxicology
► Overview of in silico tools (QSAR toolbox, iSafeRat, VEGA, OPERA, TEST, Danish QSAR Database…) and functionalities
Part 3
in silico profiling for Toxicological endpoints: Skin Sensitization and Genotoxicity
► Understanding in silico predictions (alert interpretation)
► Where to find information to be able to asses prediction reliability
► Training participants can choose the endpoints and the chemical structures to be used for specific case studies if provided in advance (be-spoke training).
Part 4
Understanding in silico prediction report formats and their validation (QPRF and QMRF)
- Digital and paper presentation material
- Free software to download and associated case studies
- Initial knowledge assessment grid
- Pre- and post-training assessment quizzes