MechoA profiler for OECD QSAR Toolbox is released !
MechoA profiler is now available as a (free) downloadable add-in to the OECD QSAR Toolbox !
After more than one year of development, we are glad to announce that the MechoA profiler v1.0 for the OECD QSAR Toolbox v4.5 has just been released! You will now be able to predict the mechanism of toxic action (MechoA) of your substances in the OECD QSAR Toolbox software.
“The Toolbox is a software application intended to […] fill gaps in (eco)toxicity data needed for assessing the hazards of chemicals. It has been developed in close collaboration [between the Organisation for Economic Co-operation and Development (OECD) and] the European Chemicals Agency (ECHA) and other actors. The Toolbox incorporates information and tools from various sources into a logical workflow. Crucial to this workflow is grouping chemicals into chemical categories. Please consult www.qsartoolbox.org
The seminal features of the Toolbox are :
- Identification of relevant structural characteristics and potential mechanism or mode of action of a target chemical.
- Identification of other chemicals that have the same structural characteristics and/or mechanism or mode of action.
- Use of existing experimental data to fill the data gap(s).”
MechoAs can be added to your installation directly from the QSAR Toolbox client. You will need to use the release from October 2021 which fixed an issue with the installation of add-ins. (Otherwise, you can see and manually download the profiler from the repository : https://repository.qsartoolbox.org/)
1. Once you have installed the Toolbox v4.5, click on the cog logo (Options) at the top-right corner of the Toolbox window.![](data:image/png;base64,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)
2. The
‘Options’ window pops up. Click on “Modules” and then on “Start QSAR Toolbox
Repository Client”.
3. A
new window pops up. Click on Check now at the bottom-right corner of this
window.
4. After the loading time, go in the
‘Options’ tab and enter your username and password to be able to connect to the
QSAR Toolbox repository (same as you used to access the download page of the
OECD QSAR Toolbox). This will be saved in the software for next uses.
5. Then go to the ‘Available’ tab. Here you will be
able to see the list of available Addins. Select “iSafeRat® Mechanisms of toxic
Actions profiler” and click on “Download now and install